Suicide Squad: Kill the Justice League is a third-person action shooter from Rocksteady Studios, creators of the Batman: Arkham series. Players control one of four members of Amanda Waller’s Task Force X: Harley Quinn, Deadshot, Captain Boomerang, or King Shark. The core objective is to eliminate the Justice League within an expansive, open-world Metropolis, a city under Brainiac's influence. Combat involves engaging enemies and utilizing distinct play styles unique to each character.

Each Squad member features unique traversal mechanics, facilitating vertical combat and free-roaming exploration across Metropolis. The game supports solo play or online cooperative play for up to four players. Post-launch content includes free additions such as new playable villains, environments, weapons, and in-game events, expanding the Metropolis environment.