Back 4 Blood is a cooperative first-person shooter from Turtle Rock Studios and Warner Bros. Games that functions as a spiritual successor to the Left 4 Dead franchise. Teams of four navigate a narrative campaign to eradicate the Ridden, parasitic hosts threatening human civilization. Players select from eight customizable Cleaners, immune survivors who possess unique perks and secondary weapons for specialized roles. A competitive PvP mode facilitates combat between human survivors and mutated Ridden variants across varied environments.

A rogue-lite Card System governs replayability, requiring players to build custom decks that counter randomized gameplay modifiers. The Game Director system monitors performance in real-time to adjust enemy spawns, environmental hazards, and the appearance of 20-foot-tall mutated bosses. These mechanics ensure that tactical requirements shift constantly throughout every mission. Turtle Rock Studios leverages its cooperative pedigree to deliver a high-stakes evolution of the horde shooter.