Yurukill: The Calumniation Games is an action-adventure title where players must solve puzzles and uncover clues to prove their innocence in a series of deadly trials. The game incorporates tense, life-or-death cross-examinations known as Maji-Kill Time, where incorrect answers can lead to failure. Players also pilot a Yurukill Fighter through virtual reality challenges, including High-Speed Quizzes and Prejudice Synapse segments.

The action-adventure gameplay is augmented by shoot 'em up sequences developed by G.rev, offering multiple difficulty options for varying player skill. A Score Attack mode is included, allowing players to compete for global online rankings.