Withering Rooms is a 2.5D horror RPG where players navigate a procedurally generated Victorian mansion that reconfigures nightly. The game involves exploring Mostyn House for resources like weapons, magical artifacts, and crafting materials, while confronting a diverse bestiary of enemies including undead, ghosts, and witches. Players can engage in item preservation rituals or permanent leveling to mitigate the consequences of death. The game expands beyond the mansion to include external locations like hedge mazes and ruins.

The RPG mechanics allow for a variety of spells, such as creating hex traps or enchanting armor. Players will encounter and interact with a cast of characters, including merchants and witches, each possessing their own motivations. Withering Rooms challenges players with its dynamic environment and combat encounters.