Handball 21 offers a realistic handball simulation, directly immersing players in competitive matches. Players manage tactics, implement game plans, coach their team, initiate set plays, and identify defensive openings to secure victory. The game emphasizes accurately reproduced handball motions and lifelike player representations, establishing itself as the most realistic handball simulation ever made.

The simulation facilitates local and online single-player and multiplayer matches. It incorporates licensed teams from top European leagues, including the French LIDL STARLIGUE and PRO LIGUE, the German Liqui Moly Handball-Bundesliga and 2. Handball-Bundesliga, and the Spanish Liga Sacyr ASOBAL. The Polish PGNiG Superliga makes its debut appearance within the game. Tactics management integrates deeply into the gameplay, shaping the on-court experience. This title represents a complete handball sports simulation.