Days of Doom is a post-apocalyptic tactical RPG roguelite where players guide survivors toward Sanctuary. The game employs turn-based combat, requiring strategic use of eight distinct character classes, each possessing unique abilities. Players recruit new heroes to bolster their community and overcome threats like zombies and raiders.

The roguelite structure ensures high replayability through over 50 randomly occurring events and more than 70 collectible items and runes. Persistent stat upgrades enhance future runs, gradually increasing the odds of reaching the final goal. The game also features hand-drawn art and an original orchestral soundtrack.