Creatura is an indie simulation game where players engineer and manage virtual ecosystems. The game guides players through evolutionary epochs, starting with single-celled organisms and progressing to complex life forms within customizable vivariums. Players utilize scientifically accurate natural and artificial selection, alongside a detailed DNA editor, to genetically engineer new species. The simulation includes managing biome characteristics to sustain these ecosystems.

Creatura offers both open-ended sandbox gameplay and educational scenarios, complete with an extensive tutorial. Players can research species, unlock advanced genetic editing techniques, and trade rare specimens. The game supports Steam Workshop for custom texture packs, allowing for further visual customization of the virtual aquariums and terrariums.